FMR LLC filed Amendment No. 2 to its Schedule 13G with the SEC on November 5, 2026, disclosing a beneficial ownership position in Caris Life Sciences Inc. as of September 30, 2026.

Key Highlights

  • Aggregate beneficial ownership: FMR LLC and Abigail P. Johnson each reported 37,795,316.66 shares beneficially owned in Caris Life Sciences Inc.
  • Percent of class: The reported holdings represent 13.4% of Caris Life Sciences Inc. common stock.
  • Sole voting power (FMR LLC): FMR LLC reported sole voting power over 37,793,788.00 shares, with zero shared voting power.
  • Sole dispositive power: Both FMR LLC and Abigail P. Johnson each reported sole dispositive power over 37,795,316.66 shares, with no shared dispositive power.
  • Event date: The date of the event requiring the filing was September 30, 2026.
  • Third-party interests: According to the filing, one or more other persons hold the right to receive or direct dividends or sale proceeds from the common stock, though no single other person's interest exceeds 5% of the total outstanding common stock.

FMR LLC and Abigail P. Johnson Disclose Large Stake in Caris Life Sciences Common Stock

According to the filing, FMR LLC, organized in Delaware and headquartered at 245 Summer Street, Boston, Massachusetts 02210, submitted Amendment No. 2 to Schedule 13G covering common stock of Caris Life Sciences Inc. (CUSIP 142152107), whose principal offices are located at 750 W John Carpenter Freeway, Suite 800, Irving, TX 75039. The amendment was signed on November 4, 2026, and reflects ownership as of the September 30, 2026 event date.

The filing reports that FMR LLC, identified as a parent holding company (type "HC"), holds aggregate beneficial ownership of 37,795,316.66 shares, equal to 13.4% of the class. FMR LLC disclosed sole voting power over 37,793,788.00 shares and sole dispositive power over 37,795,316.66 shares, with zero shared voting or dispositive power. Abigail P. Johnson, a United States citizen identified as an individual filer (type "IN"), reported the same aggregate beneficial ownership of 37,795,316.66 shares and 13.4% of the class, with sole dispositive power over all such shares and no sole or shared voting power attributed to her directly in the filing.

The filing was signed by Stephanie J. Brown on behalf of both FMR LLC and Abigail P. Johnson under separate powers of attorney. The certification states that the securities "were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer." The filing references Exhibit 99 for identification of subsidiaries through which the position is held, as required for a parent holding company filer.

What Was Disclosed

FMR LLC and Abigail P. Johnson filed Amendment No. 2 to Schedule 13G disclosing combined beneficial ownership of 37,795,316.66 shares, or 13.4%, of Caris Life Sciences Inc. common stock, based on holdings as of September 30, 2026.