Healthcare

Opthea (NASDAQ: OPT) Announces COAST Phase 3 Trial Results and Development Funding Agreement Review

Mon 24 Mar 25, 10:05 AM |

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Highlights

Opthea Limited (NASDAQ:OPT), a clinical-stage biopharmaceutical company, has announced the results of its global Phase 3 COAST (Combination OPT-302 with Aflibercept Study) trial, which evaluated the combination therapy of sozinibercept and aflibercept for the treatment of wet age-related macular degeneration (wet AMD). The trial did not meet its primary endpoint of a meaningful change in best corrected visual acuity (BCVA) after 52 weeks.

In the COAST trial, patients with minimally classic and occult lesions who received the sozinibercept combination therapy at either a 4-week or 8-week dosing regimen showed a mean change in BCVA of 13.2 letters from baseline, compared to 13.8 letters with aflibercept monotherapy. In the overall study population, the combination therapy achieved mean BCVA improvements of 13.5 and 12.8 letters for the 4-week and 8-week regimens, respectively, which were comparable to the 13.7 letters improvement seen with aflibercept monotherapy. The p-values for these comparisons indicated no statistically significant difference.

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