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Healthcare

Barclays Downgrades Cellectis (NASDAQ: CLLS) Two Notches to Underweight and Cuts Price Target to $1.30 From $9.00

1. Rating Moves Straight From Overweight to Underweight:The two-notch revision skips the neutral position entirely, signalling a wholesale change of view rather than a marginal adjustment.

Nitish Kishor | 18 September 2026

OS Therapies (NYSE: OSTX) Reaches Alignment With European Regulators on Adaptive Phase 3 Design for OST-HER2 in Resected Pulmonary Metastatic Osteosarcoma

1. European Regulatory Consensus Enables a 4Q 2026 Trial Start:Agreement on the pivotal design removes a category of procedural risk before enrolment begins.

Nitish Kishor | 18 September 2026

InMed Pharmaceuticals (NASDAQ: INM) Sees ADAR1 Capital Management Buy About $117,700 of Stock, Lifting Indirect Holding to 892,101 Shares

1. Open-Market Purchases Totalled Roughly $117,700:Buying executed at prevailing prices carries a different signal than participation in a negotiated financing.

Nitish Kishor | 18 September 2026

Nuvation Bio (NYSE: NUVB) Wins FDA Approval of IBTROZI sNDA Adding 49.7-Month Median Duration of Response Four Months Ahead of PDUFA Date

1. FDA Cleared the Label Update Four Months Before the PDUFA Target Date:Early action generally indicates a review without substantive outstanding questions.

Nitish Kishor | 18 September 2026

Biotech Clinical and Regulatory Roundup: Longeveron (NASDAQ: LGVN) Endpoint Miss, Nuvation Bio (NYSE: NUVB) Label Win, OS Therapies (NYSE: OSTX) EU Alignment and Tiziana (NASDAQ: TLSA) MS Collaboration

1. One Clear Failure and One Clear Approval Framed the Period:Longeveron (NASDAQ: LGVN) missed a Phase 2b primary endpoint while Nuvation Bio (NYSE: NUVB) secured an early FDA label update.

Nitish Kishor | 18 September 2026

Biotech Capital Markets Roundup: Aethlon Medical (NASDAQ: AEMD) Reverse Merger, MediciNova (NASDAQ: MNOV) Buy Initiation, Cellectis (NASDAQ: CLLS) Downgrade and InMed (NASDAQ: INM) Institutional Buying

1. A $180 Million Financing Anchored the Largest Structural Transaction:Aethlon Medical (NASDAQ: AEMD) agreed an all-stockMergerwith North Immunology creating NRTX at a $346.5 million pro formaEquityvalue.

Nitish Kishor | 18 September 2026

Longeveron (NASDAQ: LGVN) Phase 2b ELPIS II Trial Misses Primary Endpoint in Hypoplastic Left Heart Syndrome as Company Explores Strategic Options

1. ELPIS II Missed Its Primary Efficacy Endpoint at Month 12:The trial recorded no significant difference in right ventricular ejection fraction, with a difference of -0.7 percentage points and a p-value of 0.8336.

Nitish Kishor | 18 September 2026

MediciNova (NASDAQ: MNOV) Initiated at Buy by Roth MKM With $6.00 Price Target on MN-166 Phase 3 Programs in ALS and Degenerative Cervical Myelopathy

1. Roth MKM Opens Coverage at Buy With a $6.00 Price Target:The initiation establishes the research house first published position on the stock rather than adjusting an existing view.

Nitish Kishor | 18 September 2026

Aethlon Medical (NASDAQ: AEMD) Agrees All-Stock Merger With North Immunology Alongside $180 Million Financing, Creating NRTX at $346.5 Million Pro Forma Equity Value

1. All-Stock Transaction Creates a Renamed Company Trading Under NRTX:The combinedBusinesswill operate as North Immunology with a pro formaEquityvaluation near $346.5 million.

Nitish Kishor | 18 September 2026

Tiziana Life Sciences (NASDAQ: TLSA) Signs MOU With KAIMRC and Foundation for Neurologic Diseases to Study Intranasal Foralumab With Anti-CD20 Therapy in Non-Responding RRMS

1. Three-Party MOU Targets Non-Responding Relapsing-Remitting MS:The agreement brings together Tiziana (NASDAQ: TLSA), KAIMRC and the Foundation for Neurologic Diseases around a defined patient gap.

Nitish Kishor | 18 September 2026
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