Opaleye Management Inc., Opaleye, L.P., and James Silverman filed Amendment No. 5 to their Schedule 13G with the SEC on November 6, 2026, disclosing a beneficial ownership position in Codexis, Inc. common stock as of September 30, 2026.

Key Highlights

  • Three reporting persons: Opaleye Management Inc., Opaleye, L.P., and James Silverman each report identical beneficial ownership of 2,590,000 shares of Codexis common stock.
  • Ownership percentage: The 2,590,000 shares represent 2.37% of the class, based on 109,505,765 common shares outstanding as of August 6, 2026.
  • Shared power only: All voting and dispositive power over the 2,590,000 shares is shared; sole voting and sole dispositive power are each reported as zero.
  • Triggering date: The event requiring this filing occurred on September 30, 2026.
  • Organizational structure: Opaleye Management Inc. serves as investment adviser to Opaleye, L.P., and James Silverman exercises control over the Adviser, according to the filing.
  • Amendment number: This filing is Amendment No. 5, indicating prior filings on this position exist.

Opaleye Group Discloses Passive Position in Codexis Shares

According to the filing, Opaleye Management Inc., a Massachusetts-incorporated investment adviser, and its affiliated fund Opaleye, L.P., a Delaware limited partnership, together with James Silverman, submitted a joint Schedule 13G amendment regarding their holdings in Codexis, Inc. (NASDAQ:CDXS). Codexis is a biocatalysis company whose principal executive offices are listed at 200 Penobscot Drive, Redwood City, CA 94063. The shares in question are common stock with a par value of $0.0001 per share, assigned CUSIP number 192005106.

The filing states that the shares are held directly by Opaleye, L.P., with Opaleye Management Inc. serving as investment adviser to the fund and James Silverman exercising control over the Adviser. The outstanding share count of 109,505,765 used to calculate the 2.37% ownership figure was drawn from Codexis's Form 10-Q as reported on August 11, 2026. The filing notes that it "should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein."

Under Item 5, the filing designates this holding as ownership of 5 percent or less of a class. The certification under Item 10 states that the securities "were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer." A Joint Filing Agreement among the three reporting persons is included as Exhibit 99.1. James Silverman signed on behalf of all three parties in his capacities as President of Opaleye Management Inc., Managing Member of Opaleye GP LLC (general partner of Opaleye, L.P.), and individually.

What Was Disclosed

Opaleye Management Inc., Opaleye, L.P., and James Silverman reported a combined beneficial ownership of 2,590,000 shares, or 2.37%, of Codexis, Inc. common stock as of September 30, 2026, with all voting and dispositive power held on a shared basis and none held solely by any individual reporting person.