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Innate Pharma (Nasdaq: IPHA) Reports 42.9% ORR in Sézary Syndrome From Phase 2 TELLOMAK Trial
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Highlights
Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) presented new long-term data from its Phase 2 TELLOMAK trial evaluating lacutamab in Sézary syndrome (SS) and mycosis fungoides (MF) at the ASCO 2025 Annual Meeting. The findings, as of the October 17, 2024 data cut-off, showed durable clinical activity in patients with these advanced forms of cutaneous T-cell lymphoma (CTCL).
Lacutamab, an anti-KIR3DL2 monoclonal antibody, demonstrated an overall response rate (ORR) of 42.9% in patients with SS and 19.6% in MF, conditions characterized by poor prognosis and limited therapeutic options. Importantly, the updated median duration of response extended to 25.6 months for SS and 13.8 months for MF. These data reflect longer-lasting efficacy compared to previous interim analyses.
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