Healthcare

Eli Lilly Reports Promising Phase 2 Results for Lepodisiran in Reducing Cardiovascular Risk

Mon 31 Mar 25, 02:28 AM | Team Kalkine

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Significant Reduction: Lepodisiran lowered Lp(a) levels by up to 93.9%, meeting the primary endpoint in Phase 2 trials.

Long-Lasting Effect: A 400 mg dose sustained a 91.0% reduction for a year and 74.2% reduction for 1.5 years.

No Serious Safety Concerns: While some treatment-related adverse events were reported, no serious side effects were linked to lepodisiran.

Eli Lilly and Company (NYSE:LLY) has announced positive Phase 2 results for lepodisiran, an investigational small interfering RNA (siRNA) therapy designed to lower lipoprotein(a) [Lp(a)] levels, a genetic risk factor for cardiovascular disease. The ALPACA study results confirm that lepodisiran successfully met its primary and secondary endpoints, demonstrating a significant and prolonged reduction in Lp(a) levels.

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