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Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity. It is in Phase 3 clinical trials for treating acquired hypothalamic obesity, congenital hypothalamic obesity, pro-opiomelanocortin (POMC) and LEPR insufficiency obesities, SRC1 deficiency obesity, and SH2B1 deficiency obesity; and in phase 2 clinical trails for the treatment of Prader-Willi syndrome and MC4R deficiency. The company is also developing bivamelagon, an investigational oral small molecule MC4R agonist that is in phase 2 clinical trial for the treatment of MC4R pathway diseases; and RM-718, a next generation MC4R peptide agonist that is in phase 1 clinical trial for the treatment of hypothalamic obesity. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.
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| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -196.04M | -260.26M | -184.11M | -181.12M | -69.61M |
| Net income | -196.54M | -260.60M | -184.68M | -183.08M | -68.01M |
| Selling general administrative | 194.94M | 144.30M | 111.47M | 92.03M | 68.49M |
| Gross profit | 170.26M | 116.76M | 68.13M | 21.50M | 2.56M |
| Reconciled depreciation | 1.34M | 1.56M | 1.78M | 1.67M | 1.16M |
| Ebit | -175.46M | -239.65M | -170.22M | -179.16M | -171.22M |
| Ebitda | -174.12M | -238.09M | -168.46M | -175.92M | -170.06M |
| Depreciation and amortization | 1.34M | 1.56M | 1.76M | 3.24M | 1.16M |
| Non operating income net other | - | - | - | 3.24M | 100.45M |
| Operating income | -192.02M | -265.50M | -184.36M | -179.16M | -170.06M |
| Other operating expenses | 381.77M | 395.63M | 261.79M | 202.79M | 173.21M |
| Interest expense | 20.58M | 20.60M | 13.89M | 5.20M | 100.45M |
| Tax provision | 0.50M | 0.35M | 0.56M | - | 0.00M |
| Interest income | 15.29M | 14.71M | 13.17M | 4.03M | 0.45M |
| Net interest income | -5.29M | -5.89M | 0.81M | -1.17M | 0.45M |
| Income tax expense | 0.50M | 0.35M | 0.56M | 1.96M | -1.60M |
| Total revenue | 189.76M | 130.13M | 77.43M | 23.64M | 3.15M |
| Total operating expenses | 362.28M | 382.26M | 252.48M | 200.66M | 172.61M |
| Cost of revenue | 19.49M | 13.37M | 9.30M | 2.13M | 0.60M |
| Total other income expense net | -4.03M | 5.25M | 0.24M | -1.96M | 100.45M |
| Net income from continuing ops | -196.54M | -260.60M | -185.54M | -181.12M | -69.61M |
| Net income applicable to common shares | - | - | - | -181.12M | -69.61M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 480.20M | 392.27M | 332.75M | 382.48M | 329.52M |
| Intangible assets | 5.32M | 6.17M | 7.03M | 7.88M | 4.66M |
| Other current assets | 26.13M | 16.38M | 6.67M | 11.81M | 12.51M |
| Total liab | 210.17M | 227.72M | 162.99M | 118.22M | 45.37M |
| Total stockholder equity | 270.03M | 164.55M | 169.76M | 264.26M | 284.15M |
| Deferred long term liab | - | - | - | 75.81M | - |
| Other current liab | 91.15M | 101.90M | 48.26M | 32.89M | 30.08M |
| Common stock | 0.07M | 0.06M | 0.06M | 0.06M | 0.05M |
| Capital stock | 131.02M | 142.88M | 0.06M | 0.06M | 0.05M |
| Retained earnings | -1351.88M | -1155.34M | -894.74M | -710.06M | -528.94M |
| Other liab | - | - | - | 77.15M | - |
| Other assets | - | - | - | 16.98M | 12.14M |
| Cash | 54.30M | 89.14M | 60.08M | 127.68M | 59.25M |
| Total current liabilities | 105.94M | 115.52M | 55.20M | 39.81M | 43.43M |
| Current deferred revenue | 0.19M | 1.29M | 1.29M | 1.43M | 7.00M |
| Net debt | -50.31M | -85.20M | -58.82M | -125.73M | -56.70M |
| Short term debt | 0.65M | 1.54M | 0.77M | 0.68M | 0.61M |
| Short long term debt total | 3.99M | 3.94M | 1.26M | 1.94M | 2.55M |
| Other stockholder equity | 1491.67M | 1177.05M | 1064.30M | 974.36M | 813.04M |
| Property plant equipment | - | - | - | 2.20M | 2.81M |
| Total current assets | 466.92M | 374.20M | 308.27M | 354.24M | 308.39M |
| Long term investments | - | - | - | 16.66M | 11.81M |
| Net tangible assets | - | - | - | 256.38M | 279.49M |
| Short term investments | 334.65M | 231.43M | 215.76M | 205.61M | 235.61M |
| Net receivables | 26.08M | 18.51M | 14.87M | 6.22M | 1.02M |
| Long term debt | - | - | - | 1.34M | - |
| Inventory | 25.75M | 18.74M | 8.62M | 2.92M | 0.11M |
| Accounts payable | 13.95M | 12.33M | 4.88M | 4.80M | 5.74M |
| Accumulated other comprehensive income | -0.80M | -0.04M | 0.13M | -0.09M | -0.00M |
| Common stock total equity | - | - | - | 0.06M | 0.05M |
| Retained earnings total equity | - | - | - | -710.06M | -528.94M |
| Non currrent assets other | 3.81M | 7.79M | 15.33M | 16.98M | 12.14M |
| Non current assets total | 13.28M | 18.07M | 24.48M | 28.25M | 21.14M |
| Capital lease obligations | 3.99M | 3.94M | 1.26M | 1.94M | 2.55M |
| Long term debt total | - | - | - | 1.34M | - |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | -96.20M | -48.17M | -69.08M | 32.31M | -163.72M |
| Change to liabilities | - | - | - | -5.06M | 18.31M |
| Total cashflows from investing activities | -137.15M | -48.17M | -5.67M | 28.03M | -62.16M |
| Net borrowings | - | - | - | 72.34M | - |
| Total cash from financing activities | 217.96M | 191.24M | 74.37M | 213.83M | 166.48M |
| Change to operating activities | - | - | - | -6.66M | -16.41M |
| Net income | -196.54M | -260.60M | -184.68M | -181.12M | -69.61M |
| Change in cash | -34.78M | 29.19M | -67.60M | 68.43M | -41.68M |
| Begin period cash flow | 89.60M | 60.41M | 128.00M | 59.58M | 101.26M |
| End period cash flow | 54.82M | 89.60M | 60.41M | 128.00M | 59.58M |
| Total cash from operating activities | -115.67M | -113.88M | -136.16M | -173.43M | -146.00M |
| Issuance of capital stock | 222.69M | 178.00M | 63.01M | 131.11M | 161.73M |
| Depreciation | 1.34M | 1.56M | 1.76M | 1.67M | 1.16M |
| Other cashflows from investing activities | -40.00M | -40.50M | -5.67M | -4.00M | 102.00M |
| Dividends paid | 5.38M | 3.97M | - | - | - |
| Change to inventory | -7.47M | -10.12M | -5.71M | -2.81M | -0.01M |
| Change to account receivables | -7.57M | -3.65M | -8.64M | -5.20M | -1.25M |
| Sale purchase of stock | - | - | - | 141.49M | 166.48M |
| Other cashflows from financing activities | -19.92M | 12.87M | 25.49M | 82.72M | 4.75M |
| Change to netincome | - | - | - | 20.35M | 20.55M |
| Capital expenditures | 0.95M | 0.00M | 0.05M | 4.28M | 5.43M |
| Change receivables | - | - | - | -5.20M | - |
| Cash flows other operating | - | - | - | 0.41M | -115.26M |
| Cash and cash equivalents changes | - | - | - | 68.43M | -41.68M |
| Change in working capital | -0.97M | 10.57M | 4.81M | -19.72M | 1.90M |
| Stock based compensation | 66.82M | 39.68M | 32.55M | 19.83M | 20.80M |
| Other non cash items | 13.68M | 94.90M | 9.40M | 5.91M | -0.25M |
| Free cash flow | -116.63M | -113.88M | -136.20M | -177.71M | -151.44M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| RYTM Rhythm Pharmaceuticals Inc |
-0.50 0.54% |
92.57 | - | 555.56 | 28.37 | 70.08 | 29.19 | -12.65 |
| NVO Novo Nordisk A/S |
0.86 2.20% |
40.00 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
18.88 3.50% |
558.88 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
109.12 13.33% |
927.89 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity. It is in Phase 3 clinical trials for treating acquired hypothalamic obesity, congenital hypothalamic obesity, pro-opiomelanocortin (POMC) and LEPR insufficiency obesities, SRC1 deficiency obesity, and SH2B1 deficiency obesity; and in phase 2 clinical trails for the treatment of Prader-Willi syndrome and MC4R deficiency. The company is also developing bivamelagon, an investigational oral small molecule MC4R agonist that is in phase 2 clinical trial for the treatment of MC4R pathway diseases; and RM-718, a next generation MC4R peptide agonist that is in phase 1 clinical trial for the treatment of hypothalamic obesity. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.
| Name | Title | Year Born |
|---|---|---|
| Dr. David P. Meeker M.D. | Chairman, Pres & CEO | 1954 |
| Mr. Hunter C. Smith M.B.A. | CFO & Treasurer | 1969 |
| Mr. Joseph Shulman | Chief Technical Officer | 1975 |
| Mr. Yann Mazabraud | Exec. VP & Head of International | 1973 |
| Ms. Jennifer L. Chien | Exec. VP & Head of North America | 1975 |
| Mr. William T. Roberts | Chief Accounting Officer | 1979 |
| Mr. David Connolly | Head of Investor Relations & Corp. Communications | NA |
| Mr. Jim Flaherty | Sr. VP & Gen. Counsel | NA |
| Ms. Sarah Ryan | VP of Sales & Marketing | NA |
| Ms. Pamela J. Cramer | Chief HR Officer | 1974 |
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