Healthcare

Palisade Bio, Inc. (NASDAQ: PALI) Completes Phase 1a Dosing in PALI-2108 UC Study

Wed 09 Apr 25, 12:48 PM |

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Highlights

Palisade Bio, Inc. (NASDAQ: PALI), a clinical-stage biopharmaceutical company focused on autoimmune, inflammatory, and fibrotic diseases, has announced the completion of enrollment and dosing across multiple cohorts in its ongoing Phase 1a/b study of PALI-2108 for the treatment of Ulcerative Colitis (UC). This includes the completion of all five Phase 1a single ascending dose (SAD) cohorts, all four multiple ascending dose (MAD) cohorts, and a food effects crossover within the Phase 1a portion of the trial.

Preliminary results from the study show that there have been no serious adverse events (SAEs) or treatment-emergent adverse events (TEAEs) linked to laboratory values or EKGs. The majority of observed TEAEs were mild, with only one withdrawal occurring in the highest 50 mg twice-daily (BID) MAD cohort. Several MAD cohorts, ranging from 15 mg BID to 30 mg BID, were completed within the expected therapeutic dose range, again showing no significant safety concerns. The 15 mg BID cohort had no TEAEs, while the 30 mg BID cohort experienced a single mild TEAE.

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